Articles

Articles covering different aspects of downstream processing and manufacture of biotherapeutics

  • Re-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents

    Re-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents

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  • Quality First!

    Quality First!

    At Prometic Bioseparations we put product quality first and have committed to become the first chromatography adsorbent manufacturer to achieve full GMP compliance!

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  • Screening for chromatography adsorbent selection and optimisation for downstream processing of biopharmaceuticals

    Screening for chromatography adsorbent selection and optimisation for downstream processing of biopharmaceuticals

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  • Multi-Mode Ligand Library - Infographic

    Multi-Mode Ligand Library - Infographic

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  • Endotoxins - Infographic

    Endotoxins - Infographic

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  • Ligand Discovery Projects

    Ligand Discovery Projects

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  • Capture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF

    Capture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF

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  • Is it really cost effective to develop a custom affinity ligand as a capture step in your downstream process?

    Is it really cost effective to develop a custom affinity ligand as a capture step in your downstream process?

    We offer an extensive range of off-the-shelf Bioseparation products for the recovery and purification of biologicals as well as purification services including bespoke custom designed chromatography.

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  • Removal of Isoagglutinins from IVIG and Plasma Using Affinity Chromatography

    Removal of Isoagglutinins from IVIG and Plasma Using Affinity Chromatography

    Removal of Isoagglutinins from IVIG and Plasma Using Affinity Chromatography

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  • Multi-Mode Mimetic Ligand™ Library - a New Tool for Adsorbent Screening and Selection

    Multi-Mode Mimetic Ligand™ Library - a New Tool for Adsorbent Screening and Selection

    In response to a growing demand for rapid bioprocess development tools, Prometic has launched a new, easy to screen, library of multi-mode Mimetic Ligand™ adsorbents.

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  • Poster: Multi Mode Mimetic Ligand™ Library

    Poster: Multi Mode Mimetic Ligand™ Library

    Prometic have developed a cost effective, easy to use, rapid ‘screening toolbox’ for target protein purification - Multi-Mode Mimetic Ligand™ Library.

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  • The Evolve™ Process Column in NIBRT

    The Evolve™ Process Column in NIBRT

    It is user friendly with ergonomic elements, the performance is comparable to more expensive columns and the single use aspect of replacing all wetted components, compared to lengthy cleaning cycles.

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  • Article: Disposable Column options

    Article: Disposable Column options

    Over the last couple of years, interest has been growing in the use of pre-packed disposable chromatography columns and in the use of disposable process fluid contact pathways.

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  • Evolve™ Process Column: Customer Evaluation

    Evolve™ Process Column: Customer Evaluation

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  • Endotoxin Removal from Bench to Process Scale.

    Endotoxin Removal from Bench to Process Scale.

    Endotoxin or lipopolysaccharides (LPS) are highly toxic components of the cell wall of Gram-negative bacteria and are often present in significant amounts in bacterial cell expression systems.

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  • EtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin

    EtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin

    A number of methods have been adopted for the removal of endotoxin based on adsorption, in particular ion-exchange chromatography.

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  • Endotoxin removal & β-D-Glucan Interference

    Endotoxin removal & β-D-Glucan Interference

    EtoxiClear™ has been shown to provide >3.4 log clearance of endotoxin from Fab fragments from an E. coli cell lysate, as well as from proteins such as IgG and HSA.

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  • Immobilised Boronate Ligand Affinity Adsorbents for Glycoproteins

    Immobilised Boronate Ligand Affinity Adsorbents for Glycoproteins

    The most important application the adsorbent is as a general method for separation and purification of glycosylated from non-glycosylated proteins and often from other forms of glycosylated proteins.

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  • Capture and purification of recombinant albumin-fusion proteins using AlbuPure®.

    Capture and purification of recombinant albumin-fusion proteins using AlbuPure®.

    AlbuPure® can be used to capture and purify recombinant albumin-fusion proteins from cell culture supernatants with high purity and recovery.

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  • Capture and purification of human serum albumin from human source plasma using Mimetic Blue® SA HL P6XL

    Capture and purification of human serum albumin from human source plasma using Mimetic Blue® SA HL P6XL

    In this application note we describe how human serum albumin is captured and purified from human source plasma using Mimetic Blue® SA HL P6XL.

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