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Activation of the Free-Fatty Acid Receptor GPR40 Improves Anemia in Mouse Models of Kidney Disease via a Novel EPO-Independent Mechanism of
The prevalence of anemia increases with the progression of chronic kidney disease (CKD), and leads to reduced quality of life and increased cardiovascular risk.
PBI-4050 decreases adenine-induced tubulointerstitial injury and er-stress; implications of the GPR40 receptor
The aim of this study was to further examine the effects of PBI-4050 in both WT and GPR40 activation-/- mice on adenine-induced tubulointerstitial injury, anemia and the unfolded protein response path
PBI-4547 Prevents Progression of Prediabetic Condition to Type 1 Diabetes in NOD Mice
PBI-4547 administration in prediabetic type 1 NOD mice significantly prevented the evolution to severe diabetes resulting in increased survival.
PBI-4547 Improves Glucose Metabolism and Insulin Resistance, and Reduces Liver Damage in a High-Fat Diet Mouse Model of Obesity and Metaboli
Taken together, these results suggest that PBI-4547 offers the potential as a novel therapy for Non-alcoholic fatty liver disease (NAFLD), obesity, type 2 diabetes mellitus, and associated metabolic s
PBI-4050 Improves Metabolic Regulation and Diabetic Nephropathy through Reduction of ER Stress, Pro-Inflammatory/Fibrotic Markers, Galectin-
These results suggest that PBI-4050 is a strong potential candidate for the treatment of metabolic diseases and related diabetic nephropathy.
PBI-4547 Reverses Diabetes and Metabolic Syndrome through Regulation of Lipid/Glucose Metabolism